New study demonstrates mouthwash efficacy in viral load reduction

Featured Products Promotional Features

  Posted by: Dental Design      6th September 2021

Reducing viral transmission has never been so important across the healthcare profession. In particular, establishing methods and products that lower the risk of spreading COVID-19 has become key. Dental professionals are therefore looking for ways to minimise the viral load within patient’s oral cavities both pre- and post-treatment. This is where innovative solutions such as ‘Perio plus’ come into play – with the latest research offering even greater peace of mind than ever before.

The results are in

A new study[i] has found that ‘Perio plus regenerate’ mouthwash helps to reduce prevalence of SARS-CoV-2 viral load in saliva from the first day of use. The solution is also beneficial in reducing viral load over the next 7 days.

The multicentre, double-blind study evaluated adults aged 18-85 years from four French hospitals, all of whom were asymptomatic or showed mild clinical signs of COVID-19 (symptoms not including pneumonia) for less than 8 days. Participants were randomly organised into two groups, with one given a ß-cyclodextrin-citrox mouthwash (‘Perio plus regenerate’). Both groups received three 200ml medicine vials of ‘Perio plus regenerate’ or placebo mouthwash and were instructed to use 30ml of solution three times a day for one minute. Participants collected their own saliva as trained by nurses, just before the first, second and third mouth rinse on the first day.  Over the next six days, participants collected saliva samples at 3pm daily. Laboratory analysis determined viral count in each saliva sample.

Results from the study demonstrated a change in SARS-CoV-2 salivary viral load during the first day among all participants. However, a significant difference was observed in viral load when comparing before and after mouth rinsing between the ‘Perio plus regenerate’ mouthwash and placebo group. Participants with the

ß-cyclodextrin-citrox mouthwash also experienced a greater reduction in viral load throughout the seven days compared to the placebo group. Interestingly, there was no statistically significant difference in effectiveness when used by people with a SARs-CoV-2 viral load higher than 2.94 or those with 5.03 log10 copies/mL, suggesting that the mouthwash works well even where lower viral load exists.

Take aways

The study demonstrated that a single rinse of ß-cyclodextrin-citrox mouthwash significantly decreased the risk of SARS-CoV-2 contamination through saliva in patients with no to mild symptoms of COVID-19 4 hours after initial dose. The first rinse of the day substantially reduced the viral load detected, while follow up rinses maintained the low value – more effectively than the placebo. The authors also postulate that frequency of mouthwash could be increased for patients presenting with a higher initial viral load, in order to have greater impact on the reductions achieved. More research is needed to determine optimal mouthwash frequency and long-term impact of mouthwash use for reducing viral load in the oral cavity, but initial results with ‘Perio plus regenerate’ are certainly very promising!

Application in practice

So, what does this mean for your daily practice and your patients? Early evidence suggests that introducing a ß-cyclodextrin-citrox mouthwash such as ‘Perio plus’ could prove advantageous in minimising the risk of COVID-19 transmission through saliva. This is one further way that safety standards can be optimised, protecting both the dental team and patients and giving everyone total peace of mind. There is also an argument to be made that minimising viral load may reduce the risk of oral infection following treatment, especially where more invasive or surgical procedures are performed.

From a practical perspective, it is also a very simple and easy to implement step for patients to take prior to a dental appointment. The mouthwash can be used a few hours before a visit to the practice, and/or recommended for the 7 days following treatment to support the prevention of infection for successful healing.

Find out more

The ‘Perio plus’ range of mouth rinses, toothpaste and gel feature a unique formulation containing Citrox – a non-toxic, non-corrosive and hypoallergenic, natural bioflavonoid extracted from bitter oranges. This is combined with chlorhexidine (CHX) to offer even more powerful plaque-fighting benefits than CHX alone. To discover the full range of solutions available to your patients, visit the website today.



For more information please call 01480 862084, email or visit


[i] Carrouel F, Valette M, Gadea E, Esparcieux A, Illes G, Langlois ME, Perrier H, Dussart C, Tramini P, Ribaud M, Bouscambert-Duchamp M, Bourgeois D. Use of an antiviral mouthwash as a barrier measure in the sars-cov-2 transmission in adults with asymptompatic to mild COVID-19: a multicentre, randomized, double-blind controlled trial. Clinical Microbiology and Infection. May 2012.

No Comments

No comments yet.

Sorry, the comment form is closed at this time.